Prolactin levels are easily influenced by external factors such as sexual intercourse, nipple sucking, emotional state, exercise, full meals and hunger. What are the precautions to take when checking prolactin? Lactogen fluctuates very little during the menstrual cycle and is usually negligible, which means that it can be tested at any time of the menstrual cycle, but it should be done in the morning. Precautions: 1. Do not have sex that morning, and if you shower in the morning, avoid rubbing your nipples; 2. Avoid having your blood drawn after exercise; 3. Ask for carbohydrate-based foods, such as rice and noodles, on the same day. These have no effect on prolactin levels; 4. Avoid protein-based (e.g. milk, eggs, lean meat), fat-based (e.g. fatty meat, fats and oils) foods. How to treat hyperprolactinemia? 1.Anti-prolactin drugs Anti-prolactin include bromocriptine, long-acting bromocriptine, thioproterenol, ergometrine, ergometrine, quinacrine (norgonine) and ergometrine. (1) Bromocriptine therapy: Bromocriptine therapy is indicated for all types of hyperprolactinemia and is the drug of choice for the treatment of pituitary adenomas. (2) Cabergoline: It is a long-acting and highly effective anti-prolactin agent with good clinical efficacy and tolerability. It has a high affinity with dopamine receptor D2, directly inhibits pituitary prolactin-secreting cells and reduces prolactin secretion. Clinical observation shows that the efficacy and tolerability of cabergoline are better than that of bromocriptine, and it is a new generation drug of choice, safe and effective in the treatment of hyperprolactinemia; (3) quinacrine (norgonine): it is a non-ergot alkaloid dopaminergic agonist, and it is a new generation of specific, efficient and long-acting anti-PRL drug; (4) thioproterenol: it is a new generation of safe, inexpensive and well-tolerated anti-prolactin drug, and it is It is the drug of choice for the treatment of pituitary macroadenoma. 2.Ovulation promotion therapy is suitable for those with hyperprolactinemia, anovulatory infertility, and unsuccessful ovulation and pregnancy with simple bromocriptine treatment. It is a combination therapy based on bromocriptine and other ovulatory drugs: (1) bromocriptine-CC-hCG; (2) bromocriptine-hMG-hCG; (3) GnRH, pulse therapy-bromocriptine, etc. Combination therapy can save anti-prolactin drugs, shorten the treatment cycle and improve the ovulation and pregnancy rate. 3.Surgical treatment is suitable for giant adenoma with intracranial compression symptoms, bromocriptine treatment is ineffective, giant adenoma, suspicious cell tumor with multiple pituitary hormone secretion. The current transsphenoidal microsurgery is safe, convenient and easy to perform, and the efficacy is similar to that of bromocriptine therapy. 4.Radiation therapy is suitable for non-functional tumors of hypothalamus-pituitary system and those who are ineffective in drug and surgical treatment. At present, advanced stereotactic radiation therapy methods are mostly used, including: deep X-ray, γ, 60Co, α particles and proton rays, nuclear 90Y, 198Au pituitary implantation, etc. High prolactin friends should pay attention to: 1, pay attention to diet and exercise: eat more vegetables and fruits, eat more high-protein food, appropriate exercise. In addition, life should be regular, do not often stay up late, pay attention to rest; 2, pay attention to medication: longer-term use of drugs such as reserpine, chlorpromazine and morphine can inhibit the release of prolactin-inhibiting factors by changing the production, absorption and metabolism of dopamine, resulting in excessive secretion of prolactin, leading to amenorrhea and overflow. The reason for this is that some people who take oral contraceptives cannot get pregnant right away; 4. Pay attention to pituitary tumors: pathological hyperprolactinemia is caused by the pituitary gland in more than 80% of cases. Larger prolactinomas may also compress the blood vessels and nerves in the brain, leading to headaches and visual field loss, etc. Once symptoms appear, they need to be treated; 5, pay attention to some diseases: primary hypothyroidism, idiopathic amenorrhea and overflow syndrome, primary hyperthyroidism, renal insufficiency, bronchial cancer and other diseases can also cause elevated prolactin; 6, pay attention to self-examination: pay attention to self-examination of the breasts when bathing. If breast overflow occurs during the non-lactation period, or if abnormally elevated prolactin is found during a physical examination, it is recommended to seek medical attention at a regular hospital.