Some people with chromosomal problems have normal fertility and can get the next generation through natural pregnancy, but more people can also get healthy children by selecting chromosomally normal embryos for transfer through the third generation IVF technique. Problematic chromosomes can be categorized into structural and numerical abnormalities. Different abnormalities have different effects on fertility. Chromosomal structural abnormalities such as balanced translocations and microdeletions are common and still have some natural fertility, but embryos with chromosomal abnormalities are at a significantly increased risk of miscarriage and embryo termination. Chromosome number abnormalities are common, such as sex chromosome deletions, chromosome trisomy, etc. This has a greater impact on fertility, and it is usually difficult to obtain a natural pregnancy. In the above cases, the chromosomal condition of sperm, egg and embryo can be tested by third generation IVF technology, and chromosomally normal embryos can be selected for transfer, which can also improve the fertility of patients with chromosomal abnormality and obtain a healthy next generation.