Glutamyl transpeptidase 59 is on the high side, which may be caused by physiological factors such as staying up all night and alcoholism, or pathologic factors such as biliary tract obstructive diseases and acute and chronic hepatitis. 1. Physiological factors: when there is long-term alcoholism, staying up late, overwork or taking certain drugs, it will lead to certain damage to liver cells, so that glutamyl transpeptidase is elevated. This is generally physiologic, and will gradually be relieved after improving lifestyle, usually without obvious discomfort. 2. Pathological factors: such as gallbladder stones, bile duct stones and other biliary tract obstructive diseases will lead to glutamyl transpeptidase discharge obstacles, so that the concentration of serum increased. Liver diseases such as acute and chronic viral hepatitis, alcoholic liver, fatty liver, cirrhosis and so on, the liver cells will be damaged or even necrosis, which will also lead to the elevation of glutamyl transpeptidase in patients. In addition, pancreatitis, pancreatic tumors, prostate tumors and other diseases, glutamyl transpeptidase will also be mildly elevated. If the patient has high glutamyl transpeptidase for a long time or repeatedly, it is recommended to consult a doctor in time to find out the cause of the disease and carry out targeted treatment, so as to avoid delaying the condition.