Cold-induced ear stuffiness is caused by pathogenic microorganisms retrograde through the Eustachian tube causing secretory otitis media, Eustachian tube pharyngeal orifice oedema obstruction and secretion blockage of the Eustachian tube to cause disease. The medication needs to be different for different reasons. 1. Secretory otitis media: cefuroxime tablets, prednisone acetate tablets and other medications can be applied under the guidance of physicians. Ineffective conservative treatment can be carried out tympanotomy (for patients whose fluid is too viscous to be suctioned out, or whose fluid still generates and accumulates rapidly after repeated puncture and suction), tympanotomy with tubing (for chronic secretory otitis media with prolonged or recurring disease) and other treatments. 2. Eustachian tube pharyngeal oedema obstruction: for clear bacterial infection, azithromycin tablets, cefixime tablets and other antibacterial drugs can be applied, together with the application of glucocorticoid drugs (prednisone, dexamethasone) to treat. 3. Secretion obstruction of the eustachian tube: bacterial infection characteristics, can be applied to cefixime tablets, amoxicillin capsules and other antibacterial drugs to treat, with the application of budesonide nasal spray nasal spray and other ways of integrated treatment. This symptom needs to go to the hospital, systematic examination to clarify the diagnosis and the degree of the disease, follow the doctor’s instructions to standardize the use of drugs and treatment.