SLE is an autoimmune disease with systemic multi-tissue and organ involvement. Currently, aggressive treatment can lead to long-term remission of the disease with a good prognosis, but there is a lack of a cure for SLE. The principles of SLE treatment are to induce remission with active drugs or to keep the disease at low disease activity, to protect the function of important organs, and to reduce drug side effects. Treatment is divided into two phases: induction of remission and maintenance therapy. The general treatment includes patient education to build up the patient’s self-confidence through psychological counseling. Pay attention to rest, avoid overexertion, and avoid sun exposure. Active control of coexisting diseases. For patients with milder conditions, such as fever or joint pain only, symptomatic treatment with antipyretic and analgesic drugs can be used. At present, the main drugs are: 1. Glucocorticoids, such as prednisone and methylprednisolone are the basic drugs for the treatment of SLE, and the dosage can be slowly reduced after the condition is stabilized. For patients with critical conditions, hormone shock therapy can be used. In the application of glucocorticosteroids, the adverse effects should be closely monitored. 2. Immunosuppressants, including cyclophosphamide, mycophenolate, azathioprine, etc., can effectively protect organ function, reduce hormone dosage and reduce disease recurrence. The application should also pay attention to the infection and bone marrow suppression. 3. In critical cases, immunoglobulin injection, plasma exchange, and mesenchymal stem cell transplantation can be performed. Patients with combined antiphospholipid syndrome can be treated with warfarin anticoagulation. The performance of SLE varies from patient to patient. Generally, active treatment and intervention for concurrent diseases can have good therapeutic effects and achieve long-term remission, but each patient’s treatment needs to be individualized.