Recently, the Department of Thoracic and Cardiovascular Surgery of our hospital successfully performed a total lumpectomy “right giant alveolopexy + radical resection of esophageal cancer” for a patient with esophageal cancer combined with giant pulmonary alveoli. The patient recovered quickly with mild postoperative pain, good recovery of respiratory function and strong coughing sputum. 60-year-old Master Li, who had poor feeding for one month, visited our hospital and was diagnosed with esophageal cancer. After preoperative perfect examination, he was also found to have a combination of huge pulmonary alveoli occupying about 50% of the right side of the chest cavity and deviated lung function. With poor lung function, surgery for either of the two diseases was a huge challenge for both the patient and the surgeon. Director Zhang Zhuang, and Vice President Zhang Shuanglin led the medical staff in consultation and decided to perform a total lumpectomy “right giant alveolopexy + radical esophageal cancer resection for the patient.” Four small 0.5-1.0 cm holes were first taken in the chest and lumpectomy instruments were placed to perform resection of the right giant alveoli, and every effort was made to preserve the healthy lung tissue for the patient. After that, the thoracoscopic resection of the thoracic esophagus and the clearance of mediastinal lymph nodes were performed, and the laparoscopic resection of the stomach and lower thoracic esophagus and the clearance of the left gastric and cardia lymph nodes were performed, and finally the gastroesophageal neck anastomosis was completed. According to traditional radical esophageal cancer surgery, incisions have to be made in one place in the chest or three places in the chest, abdomen and neck, which involves the chest and abdomen, causing great damage, obvious postoperative pain, difficulty in coughing up sputum, high pulmonary complications, slow postoperative recovery and expensive medical expenses. With the development of minimally invasive surgery technology, the application of thoracoscopy and laparoscopy has gradually become popular. Thoracoscopic radical esophageal cancer surgery has faster recovery after surgery, and because of the small impact on postoperative lung function, some patients with poor lung function and general condition can also tolerate the surgery, and the field of view during lymph node dissection is better than that of open-heart surgery. However, due to the complicated anatomy and difficulty of esophageal cancer surgery, thoracoscopic esophageal cancer surgery is only carried out in a few famous hospitals in China. After the successful introduction of thoracoscopic esophageal cancer surgery technology in our hospital, lumpectomy has now accounted for 90% of esophageal cancer surgery. The success of this case marks another innovative breakthrough of minimally invasive thoracic surgery technology in our hospital.