The pain in the middle of the chest when holding up the breast may be physiological, and may be related to pathological factors such as trauma, soft tissue aseptic inflammation, breast disease, etc. 1. Physiological factors: such as recent strenuous exercise or fatigue, causing acid metabolism local accumulation, stimulation of the peripheral nerves around the chest triggered by the pain, especially in the activities or chest up obvious, after resting can be gradually relieved on their own. 2. Pathological factors (1) Traumatic injury: if there is fracture or bone crack in the chest, the fractured part will be displaced during activity, which may cause compressive stimulation or injury to the peripheral nerves, and cause pain in the middle of the chest when holding out the chest. (2) Soft tissue aseptic inflammation: such as costochondritis, inflammatory stimulation can be caused by chest pain in the middle of the chest when lifting the chest, and may also be accompanied by local skin redness, swelling, elevated temperature and other symptoms. (3) Breast disease: mostly seen in middle-aged women, the pain in the middle of chest when holding out the chest can be caused by the proliferation of malignant tumors of the breast and the tugging pain in the middle of chest. If you have pain in the middle of chest when holding up your chest, we suggest you to consult a doctor in time, and treat it positively after clear diagnosis, so as to avoid delaying the condition.