Bisoprolol fumarate tablets are not recommended when the heart rate is less than 60 beats per minute, and patients with myocardial ischemia not amenable to reperfusion therapy and a heart rate of less than 50 beats per minute need to discontinue the drug or reduce the dosage. Normal human heart rate is 60 to 100 beats per minute, bisoprolol fumarate tablets are mainly used in the treatment of essential hypertension, angina pectoris, has the effect of reducing the heart rate, so if the heart rate is lower than normal, less than 60 beats per minute need to stop or reduce the amount of drugs. If the patient suffers from severe myocardial ischemia, but can not be reperfusion therapy, these patients can take drugs to further reduce their heart rate to 50 beats per minute, at this time can be used in small doses of bisoprolol fumarate tablets. Note that the drug is contraindicated in shock, atrioventricular conduction disorders (second- and third-degree atrioventricular block), sick sinus syndrome, sinus block, low blood pressure, bronchial asthma, and severe peripheral circulatory disorders, and bisoprolol fumarate tablets should be taken with caution in diabetic patients with fluctuating blood glucose concentrations, acidosis, and severe hepatic and renal insufficiency. If the heart rate drops during treatment, seek medical help and change the medication if necessary to treat the original disease.