Cheek skin pain when pressed may be temporomandibular joint disorder syndrome, contact dermatitis, wisdom teeth pericoronitis, as well as shingles and other causes. 1. Temporomandibular joint disorder syndrome: the cause of temporomandibular joint disorder syndrome has not been clearly defined, and it is considered to be caused by trauma inside and outside the joints, disorders of masticatory muscles, and mental and psychological factors. Patients will have pain in opening or closing the mouth, pain in the temporomandibular joint area, muscle pain, tenderness and pressure pain and other manifestations. If the patient has temporomandibular joint disorder syndrome, it will be manifested as pain when the skin of the cheek is pressed. 2. Contact dermatitis: contact dermatitis may be caused by contact with sensitizing substances and primary irritants. The patient’s lesions will appear burning pain, itching, erythema, blisters, papules, papules and other manifestations. Therefore, patients with contact dermatitis in the cheek area may show pain when pressed. 3. Wisdom tooth pericoronitis: Wisdom tooth pericoronitis may be caused by incomplete eruption of wisdom teeth and improper position of wisdom teeth when erupting. Patients will have symptoms such as redness and swelling of the gum flap, pain, difficulty in opening the mouth, chills, tiredness, congestion and edema of the cheeks, difficulty in opening the mouth, and enlarged lymph nodes in the lower jaw. If the patient has pericoronitis of wisdom teeth, there will be the symptom that the skin of the cheek is painful when pressed. 4. Others: Painful cheek skin on pressure may be caused by herpes zoster, boils and other reasons. It is recommended that patients with pain on cheek skin need to consult a doctor in time, and the doctor needs to clarify the cause of the disease and then treat it.