Severe chronic atrophic gastritis with moderate intestinal chemosis suggests the possibility of deterioration, and it is recommended to take omeprazole, bismuth potassium citrate, amoxicillin and other medications to treat it, and to be vigilant for the progression of atrophy and intestinal epithelial chemosis to gastric cancer. Chronic gastritis, Helicobacter pylori infection is a common cause. Anti-Helicobacter pylori treatment, commonly used is quadruple therapy, including a proton pump inhibitor, a bismuth agent, and two antibiotics. Commonly used proton pump inhibitors include omeprazole, lansoprazole, etc.; bismuth agents include bismuth potassium citrate, bismuth pectin, etc., and antibiotics commonly used include amoxicillin and clindamycin. Under the premise of eradicating H. pylori, it is necessary to supplement multivitamins in moderation, eat more fresh food, and avoid drinking and smoking. Regular review, if diagnosed with gastric cancer, early surgical treatment should be carried out. Severe chronic atrophic gastritis with moderate intestinalization should be regulated under the guidance of the doctor for early treatment to reduce the adverse effects of the disease.