Inflammation and swelling of the fistula in front of the ear indicates an infection, which requires oral antibiotics in mild cases and surgical incision to drain the pus in severe cases. Pre-auricular fistula is a congenital malformation caused by the incomplete development of the auricular tissue during the embryonic period of a child’s life. Once infection occurs, the fistula can be repeatedly inflamed pus, repeated ulceration, it is recommended that patients who have already had a preauricular fistula infection timely surgical treatment. In mild cases, patients can be given localized wet compresses of isacridine solution, physical therapy, oral antibiotics (such as amoxicillin, cefuroxime, etc.) to actively control the infection. If the infection has accumulated into an abscess, it is necessary to make an incision and drain the pus in time. After the disease is controlled and stabilized, fistulotomy can be chosen to avoid recurrence. Patients are advised to seek early medical treatment to avoid accumulation of pus and development of abscess. The above drugs should be taken under the guidance of a professional physician to avoid serious adverse reactions.