Early symptoms of childhood leukemia include physical discomfort such as body pallor, weakness, etc., fever, anemia and bleeding. 1. Anemia: it appears earlier, mainly due to the inhibition of bone marrow hematopoietic stem cells. There will be symptoms such as pallor, lack of energy, weakness and low appetite. 2. Fever: caused by infection or leukemic fever, antibiotic treatment may be effective, infection is mostly high fever; leukemic fever is mostly low fever, antibiotic treatment is ineffective. Fever may be variable, low fever, irregular fever, persistent high fever or flaccid fever. 3. Bleeding: skin and mucous membrane bleeding, manifested as purpura, gastrointestinal bleeding and hematuria are common. There are other symptoms of early childhood leukemia, such as enlarged liver, spleen and lymph nodes.