Itching of the vulva in the middle of the night may be caused by vulvovaginitis or vaginitis, drug allergies, chemical irritation and so on. The symptoms of itching may be caused by vulvovaginitis or vaginitis, drug allergy or chemical stimulation. It is recommended to go to the gynecology department of the regular hospital to do the relevant examination, antibacterial and anti-inflammatory treatment for the cause, or physical therapy. Usually keep the vulva clean and dry, do not use soap and other stimulating substances to wash the vulva. Use loose, breathable cotton fabrics for underwear, don’t wear those chemical fiber underwear, and don’t wear tight pants, so as not to aggravate the condition. When itching, avoid scratching the affected area with hands or instruments. Usually take more water and don’t eat spicy and irritating food. Appropriate vitamin supplement, eat more vegetables and fruits, pay attention to balanced nutrition.