Patients sleep up with chest pain, the common causes are mainly the following: First, the patient sleeps at night in an improper posture, which can cause continuous pressure on the chest, causing spasmodic pain in the local muscles. At this time, the patient can through the chest muscles at the appropriate massage, improve local blood circulation, after sufficient rest, the patient’s chest muscle pain symptoms can be relieved faster. Second, patients with coronary atherosclerotic heart disease, sleep up after appropriate activities to increase the heart’s oxygen consumption, causing irregular spasmodic contraction of the heart, can cause heart ischemia, hypoxia, chest pain symptoms. At this time, patients can take oral nitroglycerin tablets to improve the symptoms of cardiac ischemia and hypoxia. If the patient is still accompanied by pain, it is recommended to go to the hospital as soon as possible to complete the coronary angiography examination, to clarify the severity of cardiac stenosis, and if necessary, to carry out interventional therapy to restore blood flow to the heart and alleviate the symptoms of pain.