Holding in the middle depression below the two chests may be caused by pneumonia, pleurisy, coronary heart disease and other diseases, and it is recommended that medication and other treatments be taken to relieve the symptoms according to the cause of the disease. 1. Pneumonia: after inflammation repeatedly stimulates the lung tissue causing inflammatory edema, there will be dyspnea, shortness of breath, chest tightness and other symptoms. In case of bacterial infection, drugs such as cefixime and cefradine should be taken orally to reduce inflammation; and regarding viral infection, ribavirin should be taken orally in time to fight against the virus. When chest tightness is serious, inhalation nebulization treatment with glucocorticoid drugs, such as dexamethasone, can be considered. 2. Pleurisy: when inflammation stimulates the pleural tissue causing pleural effusion, there may be symptoms of chest tightness. When there is bacteria, oral cefaclor and cefixime can be used to reduce inflammation; while for Mycobacterium tuberculosis infection, oral isoniazid and rifampicin can be used, and when there is pleural effusion, puncture and drainage can be performed. 3. Coronary heart disease: when the coronary artery stenosis, affecting the normal oxygen supply to the myocardium easily cause chest tightness. For stable angina, sublingual nitroglycerin and isosorbide nitrate should be taken as soon as possible. And about unstable angina needs immediate perfusion therapy after evaluation. Those with myocardial infarction can consider intervention. At present, there are symptoms of chest tightness, it is recommended to do cardiac ultrasound, electrocardiogram, coronary angiography and other tests for diagnosis and analysis as soon as possible, to understand the cause of the disease, and then follow the doctor’s instructions to carry out standardized treatment.