Angong Niuhuang Pill is more effective for patients with cerebral infarction when they cause impaired consciousness, and the drug is a wake-up drug with brain-awakening effects. Patients with cerebral infarction who have impaired consciousness are usually seen in large cerebral infarction, including drowsiness, lethargy and coma, and also including decortical state, vegetative state, blurred consciousness and delirium state. When there is impaired consciousness, the patient should be given brain-awakening treatment. Commonly used brain-awakening drugs include brain-awakening medication, compound musk, Qingkailing injection, and Angong Niuhuang pill. If the patient has impaired consciousness, most of them have cerebral edema and increased intracranial pressure, so they should be given cranial pressure-lowering treatment, including mannitol, glycerol fructose, tachyphylaxis and sodium β heptaerythroside. Most of the patients have severe physical symptoms and signs, and when the condition is stabilized, rehabilitation, acupuncture, and butalbital can be given to improve the symptoms and signs of neurological deficits.