The gurgling of the stomach at night without eating may be related to physiological factors such as hunger or pathological factors such as chronic enteritis, which can be treated by eating, taking drugs such as ofloxacin. 1. Physiological factors: because of long time without food, the human body feels hungry, there may be intestinal hyperpnoea, which is manifested as stomach grumbling, usually after eating properly, the symptoms will gradually disappear. 2. Pathological factors (1) Chronic enteritis: patients may have abdominal pain, diarrhea, nausea and other symptoms, can also lead to intestinal hyperacute, manifested as rumbling, can use quinolone antibiotics, such as ofloxacin, etc. for treatment. (2) Intestinal dysfunction: patients may also show symptoms such as hyperactive bowel sounds, diarrhea, etc. Probiotics such as bifidobacteria can be taken to regulate the intestinal flora. In addition, patients should pay attention to eat light and easy to digest food in daily life, do not eat cold, spicy and other stimulating food. The above drugs are prohibited for those who are allergic to them and should be taken in accordance with medical advice. If the patient’s stomach rumbling symptoms are serious, or continue to see no improvement, it is recommended to go to the regular hospital in a timely manner, after clarifying the cause of the disease, under the guidance of the doctor for targeted treatment.