Cranial defect is a relatively common craniofacial disorder, especially in modern society, where traffic safety accidents and production safety accidents are frequent, which are likely to cause injuries to the skull, and craniofacial surgery may also damage the skull in many cases. Therefore, the incidence of cranial defects is relatively high. After the occurrence of cranial defects, timely cranial repair becomes an urgent issue. If it is not repaired in time, it will cause great damage and many adverse effects to the organism. In a large range of cranial defect, the patient’s scalp may be sunken due to atmospheric pressure, which may lead to intracranial pressure imbalance, brain tissue displacement, as well as reduced blood flow to the cerebral hemispheres and disturbance of cerebrospinal fluid circulation, thus causing a series of clinical manifestations, mainly including: headache, vertigo, irritability, epilepsy, no other causes of discomfort and various mental disorders. Cranial repair surgery is a very mature technique, and it is more about the choice of repair material. Polyether ether ketone (PEEK) material is currently a very ideal material for cranial repair, and it is a polymer material that is very close to autologous cranial bone. Compared with the traditional titanium mesh material, it has very big advantages. For example: 1. Good biocompatibility, no allogeneic reaction. 2, 3D printing, perfect shaping. 3.Radiation is transmissible and will not affect the postoperative CT MRI. 4, embedded repair, perfect fit in the bone window, smooth articulation, will not produce cutting line stimulation injury. 5.It will not be too sensitive to the external hot and cold environment. 6, high hardness, can play a very good protection role.