Patient: I am a hepatitis B major triple-positive patient, I have been treated for more than a year and stopped taking the medication on March 12, 2010 (before taking Boludin), now my liver function is normal and DNA quantification is negative, now I want to get pregnant, but because I just stopped taking the medication, I don’t know if there is any effect? And if I want to get pregnant, what should I pay attention to in order not to infect my child? Zhao Zhixin, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University: It is recommended not to be too eager to conceive, but to observe whether the virus recurs after stopping the drug and whether the liver function can be maintained normally. It is better to recheck the liver function and virus quantification every month. Otherwise, there is a recurrence, plus pregnant with a small child. It will be difficult to deal with some. In order not to infect the child, the main thing is to have the hepatitis B vaccine and hepatitis B immune protein when the child is born. Some places or departments give hepatitis B immune protein in the second trimester. Not against it, but most hepatitis specialists think it can be of little use. Patient: Thank you, doctor. One more question: Is it possible to stop the medication for at least three months before getting pregnant? I have consulted an infectious disease doctor before and he said that I don’t need to wait until after three months, I can get pregnant after stopping the medication, but there are some doctors who say that I can get pregnant only after at least three months? Zhao Zhixin, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University: If we talk only about the medication, it is possible to get pregnant in three months. But what I said above, you probably didn’t understand, that is, after stopping the medicine, you have to observe whether the virus will recur, if not, it will be better to conceive again, otherwise, once you have a small child, plus the virus recurrence, you will be very difficult to get. So, it is recommended that you do not want so urgently. Patient: Oh, okay, thank you Dr. Zhao, I will go for a checkup in the near future, what are Dr. Zhao’s office hours? Zhixin Zhao, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University: I work on Thursday morning. The results are as follows: Ultrasound description: left liver upper and lower diameter: 73 mm, left liver anterior and posterior diameter: 44 mm, right liver oblique diameter: 124 mm, portal vein diameter: 9 mm. liver morphology is basically normal, liver is not significantly enlarged or shrunken, liver surface is smooth, liver parenchymal echogenicity is thickened and evenly distributed, no obvious occupying lesions are seen in the liver. The intrahepatic vessels were still clear. Gallbladder wall thickness: 5.6 mm. the gallbladder was not large and the wall was not smooth. No obvious solid light masses were seen in the gallbladder lumen. The intra- and extrahepatic bile ducts were not dilated. The splenic intercostal thick diameter: 36 mm, splenic long diameter: 92 mm, splenic portal vein inner diameter: 6 mm. the spleen was normal in size and morphology, with clear contours and intact envelope. no obvious occupying lesions were seen in the spleen. The pancreas was normal in size and morphology, with a clear outline and uniform internal echogenicity. Ultrasound suggested that the liver parenchyma was uniformly thickened with no significant enlargement or shrinkage of the liver, and no obvious occupying lesions were seen in the liver. Chronic cholecystitis was detected. No dilatation of the intra- and extrahepatic bile ducts was seen. The spleen ultrasonography did not show any significant abnormality. No significant abnormalities were seen on pancreatic ultrasound. My questions are: 1. Please help me see if there are any problems with the ultrasound results? 2. Does the ultrasound indicate chronic cholecystitis, which means I have chronic cholecystitis? (Note: I usually have no symptoms or discomfort related to this) 3. Does it affect my pregnancy? (I am preparing for pregnancy recently) 4. Will chronic cholecystitis affect my liver function? Zhao Zhixin, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University: Nothing too much of a problem. Chronic cholecystitis is mostly related to your chronic hepatitis B. If there are no symptoms, it usually does not affect, some patients can affect the liver function. The liver and gallbladder are affected by each other. Patient: Dr. Zhao, I had my liver function and DNA quantification reviewed at your hospital on June 4, and the test results were normal, but the DNA quantification was 1.41e7 IU/ml. Can I get pregnant in this case? Yes, but the liver function should be rechecked monthly.