Serum triglycerides are one of the components of blood esters. Triglycerides are in a dynamic balance in the body. The level of blood esters can change with dietary changes and can vary widely. In addition, their levels increase with age, and tend to be higher especially in middle-aged and older adults who are overweight. What can cause elevated serum TG levels? Triglycerides fluctuate over a wide range, varying with age, gender, diet structure and lifestyle habits. Triglycerides in the body are mainly synthesized in the liver and adipose tissue, but can also be absorbed from food via the small intestinal mucosa. Serum triglycerides are mainly found in very low density lipoproteins (VLDL) and celiac particles (CM), and hypertriglyceridemia is one of the risk factors for cardiovascular disease. Common causes of hypertriglyceridemia include diabetes mellitus, hypothyroidism, obesity, alcohol consumption, nephrotic syndrome and the use of certain medications such as beta-blockers, diuretics, estrogens, glucocorticoids, immunosuppressants, triamcinolone acetonide, antipsychotics and protease inhibitors. Less common causes include acromegaly, glycogen accumulation, hypopituitarism, congenital or acquired fat metabolism disorders and systemic lupus erythematosus. Although hypercholesterolemia is the most common dyslipidemia associated with renal disease such as nephrotic syndrome, hypertriglyceridemia is also not uncommon. The mechanism of dyslipidemia in renal disease is mainly due to increased synthesis of VLDL and LDL, but it is also thought to be related to slowed metabolism of these lipoproteins. In obese patients, VLDL production is significantly increased due to excessive hepatic synthesis of apolipoprotein B. In addition, obesity often coexists with other metabolic diseases. The increase in triglycerides is more pronounced in abdominal obesity than in hip obesity. Approximately 80% of patients with gout have hypertriglyceridemia, and conversely, 80% of patients with hypertriglyceridemia also have hyperuricemia. This relationship is also influenced by environmental factors, such as excessive intake of simple sugars, heavy drinking and the use of thiazides.