Hyperpigmentation, creams to remove melanin deposits include hydroquinone cream, retinoic acid cream, azelaic acid, and so on. Melanin deposits are related to ultraviolet radiation, stress, partiality, lack of sleep, endocrine disorders, nutritional status and other conditions. 1. Hydroquinone Cream: Hydroquinone cream is commonly used in the clinic for the treatment of melanin deposits. Hydroquinone cream is a western medicine, a skin discoloring agent, which can be used in the treatment of freckles, chloasma, and post-inflammatory hyperpigmentation spots. 2. Vitamin A Acid Cream: Vitamin A acid cream, also known as vitamin A acid cream, can be used for conditions such as acne vulgaris and flat warts. It can also help induce epidermal hyperplasia, help prevent skin aging, and assist in removing hyperpigmentation. 3. Azelaic acid: azelaic acid is commonly used in the form of ointment or gel, and is a commonly used dermatologic drug. It can be used for the topical treatment of mild to moderate inflammatory acne vulgaris. Azelaic acid ointment has an inhibitory effect on tyrosinase competition in hyperfunctional melanocytes, which can reduce melanin synthesis. There are more drugs to remove skin pigmentation, it is recommended to use them reasonably under the guidance of a doctor, but also to understand the adverse reactions and contraindications of the drug.