The red spots on the ankles may be caused by allergic purpura and eczema, which can be treated with medication and physical therapy. 1. Anaphylactic purpura: Anaphylactic purpura is considered to be caused by microbial infections or animal protein allergies, which can lead to localized skin purpura, causing many red spots on the ankles, and may also cause low-grade fever and fatigue. It is necessary to remove the local lesions and avoid foods and drugs that may cause sensitization. You can take loratadine tablets, chlorpheniramine maleate tablets and other drugs to control the development of the disease. 2. Eczema: Allergy is an important reason for the occurrence of eczema, and the allergens can come from outside or inside the body. It can cause a lot of red spots on the ankles and also trigger an itchy feeling. You can apply hydrocortisone butyrate cream, mometasone furoate cream and other drugs, can play the role of anti-itching and anti-allergy, if it is a chronic eczema can also choose ultraviolet therapy treatment. There are a lot of red spots on the ankles also consider folliculitis, insect bite dermatitis, etc., the patient needs to go to the hospital in a timely manner, and the use of drugs under the guidance of the doctor, do not blindly use their own medication.