Acne around the mouth and lips is mostly considered to be acne, and the treatment includes topical medication, oral medication, and physical therapy, etc. The treatment includes topical medication, oral medication, and physical therapy. 1. Topical medication: Generally, topical retinoids, such as retinoic acid ointment, adapalene gel, etc., can be used to dissolve acne, improve follicular keratinization, and reduce inflammatory reaction; topical benzoyl peroxide can be used to anti-inflammatory and dissolve acne; topical azelaic acid can be used to inhibit the growth of Propionibacterium acnes; topical antibacterials, such as ciprofloxacin and mupirocin, can be used to fight infections when they are accompanied by infections. 2. Oral drug therapy: for patients with moderate to severe acne, oral antibacterial drug therapy, such as minocycline, doxycycline, etc.; oral isotretinoin therapy, etc., which should be selected according to the condition. 3. Physical therapy: for those who cannot tolerate drugs, photodynamic therapy and chemical peeling therapy can also be taken. It is recommended that patients go to the dermatology department of regular hospitals, follow the doctor’s instructions to clarify the diagnosis, reasonable treatment, not blindly self-medication.