Blue eye, medically known as “blue sclera”, is an important symptom of many diseases, most often seen in “osteogenesis imperfecta”, a condition in which the sclera is translucent and reveals a blue color. This is a condition in which the collagen fibers of the sclera are underdeveloped, making the sclera translucent and revealing the blue color of the uvea. “Osteogenesis imperfecta” is a hereditary disease, bone brittle, deafness, blue sclera is its three major basic manifestations, mild cases can be asymptomatic, normal height, usually life expectancy, only mildly susceptible to fracture. In severe cases, the patient is crippled and even dies. The general symptoms are increased bone fragility, minor injuries can cause fractures, often manifested as spontaneous fractures, or repeated multiple fractures. Most of the fractures are of the green branch type, with little displacement, mild pain, fast healing, relying on subperiosteal osteogenesis to complete, deformed healing is common, and the limbs are often bent or angular, and the number of fractures gradually decreases after puberty. There may be scoliosis, pelvic flattening, or short stature. Blue sclera, thinning of the sclera, and increased transparency. Progressive deafness stems from sclerosis of the auditory ossicles, impaired sound conduction or, some believe, from entrapment of the auditory nerve as it exits the base of the skull. The teeth are hypoplastic and grayish yellow, the incisors are thinned with defective margins, the joints are lax, the tendons and ligaments may be deformed due to defective development of the collagenous tissue, and the joints are unstable. Due to defective collagenous tissue there is muscle weakness and widening of skin scarring. There is no impairment of intellectual reproduction.