The development of HFMD begins with the prodromal phase, which is characterized by fever. Fever can be accompanied by many symptoms, and in some children it is more severe and can even lead to febrile convulsions because of the high body temperature. Other symptoms such as headache, sore throat, and poor mental status. In HFMD patients, a rash can appear in the isthmus, and when the rash breaks down, it can lead to significant sore throat, which is obvious when swallowing. When a rash appears, it is usually on the skin of the hands, feet, and buttocks. The rash is mainly in the form of red papules and herpes, and the skin between the rashes may have a normal color. The rash usually appears 1-2 days after the onset of fever, and after the rash appears, a new rash may appear continuously in the first 2-3 days or even on the fourth day, and most children will not have a new rash after the fourth day, and the existing rash will gradually fade away. By this time, the child’s temperature usually drops to normal and the symptoms disappear completely within a week or so. In some children with severe HFMD, the temperature may not drop on the third or fourth day, but may rise repeatedly, with symptoms affecting the central nervous system, such as drowsiness, headache, easily startled, and shaking of the limbs, etc. Such severe HFMD patients should be taken seriously clinically.