Herpes is a skin disease caused by the human herpes virus, the common clinical herpes simplex, chickenpox and herpes zoster, each disease has both similarities and differences in transmission. 1, herpes simplex: mainly through direct contact transmission, the transmission route includes oral-oral transmission, oral-genital transmission, genital-genital transmission. In addition, infection can also be caused by indirect contact with contaminated supplies, such as pajamas, toys, towels, utensils, etc. 2, chickenpox: chickenpox patients are the main source of infection, the virus is stored in the patient’s herpes fluid, blood, nasopharyngeal secretions, can be transmitted through air droplets, direct contact with herpes fluid or contaminated utensils, blood donors in the incubation period of the disease can be transmitted through blood transfusion. In addition, pregnant women with chickenpox 6 days before delivery can infect the fetus; 3. Herpes zoster: and chickenpox are caused by the same virus, namely chickenpox-herpes zoster virus. The virus enters the body through the respiratory tract when first infected and shows up as chickenpox, then the virus is latent in the posterior root ganglion of the spinal cord, and once the body’s resistance decreases, the virus can activate and replicate again causing herpes zoster. In patients with shingles, the virus is only present in the herpes fluid and cannot be transmitted to others through the respiratory tract or blood. Children who have never been exposed to the varicella-zoster virus may contract chickenpox without manifesting as herpes zoster when first exposed to the herpes zoster patient’s herpes fluid. Varicella and herpes zoster can be prevented by vaccination, and respiratory and contact isolation should be used for varicella and contact isolation for herpes zoster. Herpes simplex is particularly aware of the risk of sexual transmission and no intercourse during the illness.