Genetic spots, which may be spots on the face such as freckles and birthmarks, may be present in early childhood or at birth. They can be treated by liquid nitrogen freezing, laser and surgery, and most of them can be removed effectively. 1. Freckles: The cause of freckles is related to heredity and may be aggravated by exposure to ultraviolet rays. Freckles do not affect physical health. If the freckles are severe, they may affect beauty or mental health. Topical application through hydroquinone cream, retinoic acid and other medications can promote pigment metabolism to lighten the discoloration. Freckles can be eroded and peeled off through liquid nitrogen cryogenic freezing if necessary. Photorejuvenation, Q-switched emerald laser, picosecond laser, etc. can also be used to effectively remove pigmentation. 2. Birthmarks: Birthmarks include pigmented nevus, Mongolian spots, nevus of Ota, coffee spots, bright red nevus and so on. It is recommended to go to the dermatology department of the hospital, and the doctor will choose the appropriate treatment method according to the size and shape of the skin lesion. The treatments for birthmarks include liquid nitrogen freezing, ruby laser, alexandrite laser, chemical peeling, and skin resurfacing. If the birthmark is enlarged, broken, or bleeding, consider surgical excision and suturing, skin grafting, flap method, and skin expansion for treatment if necessary. It is recommended that patients with hereditary pigmentation should not be treated blindly to avoid skin irritation. They can go to a regular medical institution for consultation, find a specialist to examine their skin, and then formulate a suitable treatment plan.