The so-called hepatitis B negative, positive, generally refers to the hepatitis B surface antigen, hepatitis B surface antigen is divided into two cases: one, the hepatitis B surface antigen is negative, such a group of people need to do the five indicators of hepatitis B, to see if there are antibodies, if the hepatitis B surface antibody is positive is protective, if the hepatitis B surface antibody is negative, you need to go to the hepatitis B vaccine. Second, hepatitis B surface antigen positive, which is often referred to as infected with hepatitis B virus, for such people also need to check the five indicators of hepatitis B, and further monitoring of liver function and HBV-DNA and liver ultrasound to assess the condition.