The side effects of sertraline hydrochloride tablets are as follows: 1. The most common adverse reactions include gastrointestinal reactions, the most common of which include nausea, indigestion, and poor appetite. Because 5-hydroxytryptamine receptors still exist in the stomach, when sertraline is digested and absorbed, it acts on 5-hydroxytryptamine receptors throughout the body, and the reaction of the stomach will be manifested as an adverse reaction of gastrointestinal discomfort, which is relatively mild and will gradually subside in about two weeks after taking the drug. 2. Other serious adverse reactions include liver function impairment and emotional instability at the beginning of taking the drug, which may even aggravate the patient’s Negative perceptions, etc. In addition, patients with depressive episodes of bipolar disorder should use sertraline with caution, as it is easy to change from depressive to manic phase after taking the drug. In conclusion, after taking sertraline treatment, if an individual develops mental or physical abnormalities and feels uncomfortable, he or she should promptly seek follow-up consultation with a doctor and adjust the treatment plan to avoid the great impact of side effects.