Multiple nodules in the lungs require careful questioning of the patient’s past medical history for long-term smoking as well as dust exposure, including stonemasons, coal miners, cooks, hairdressers, tailors, etc. Long-term exposure to dust and odor irritation can lead to the formation of multiple nodules in the lungs, which are generally benign nodules. However, other changes in the lung nodules still need to be considered, as nodules are divided into three types of conditions: ground glass nodules, partially solid nodules and solid nodules. If the nodules are less than 5mm, as a possibility of chronic nodules, they belong to the possibility of benign nodules. If the nodule is between 6-8 mm, especially if it is larger than 8 mm with changes such as lobarization, pleural traction sign, short burr, etc., it is necessary to be highly alert to the occurrence of early lung cancer and further give enhanced CT examination of the chest and, if necessary, percutaneous lung puncture cytology tissue examination to clarify whether early lung cancer has occurred. In conclusion, in addition to chronic inflammation, multiple nodules in the lung need to be considered in conjunction with specific conditions, whether there are tuberculosis and tumor changes, and early treatment measures should be given.