Do I need to have a mid-term pregnancy test after having an early-term pregnancy test? No, unless it is a combined early and midterm screening test, so normally, you do not need to have a midterm test after having the early test. However, if you want to screen for neural tube defects with serology, you will need to have a blood test for alpha fetoprotein in midtrimester. If the AFP is not checked, neural tube defects need to be carefully ruled out during the midtrimester ultrasound macrosomia screening.