Gastric cancer metastasis of liver cancer in advanced stage with severe pain can be treated by general therapy, symptomatic supportive therapy, pain relief therapy, active anti-tumor therapy and so on. The principle of treatment for advanced cancer is to try to prolong the patient’s life and minimize the patient’s pain. 1. General treatment: patients need to adjust their mindset appropriately, and their family members and children should give them company and encouragement. 2. Symptomatic supportive treatment: as the patients in advanced stage of cancer have unbearable pain or cannot eat, they can cooperate with intravenous drip supportive treatment. 3. Analgesic treatment: painkillers for advanced cancer are currently used in the international three-stage pain-relieving method. Non-steroidal anti-inflammatory drugs, such as ibuprofen, etc., can be chosen firstly; patients with gradually aggravating pain can choose opioid painkillers, such as aminophenol tocopherol tablets, etc.; when the painkillers are ineffective in the above two types of medicines, morphine and other medicines can be chosen for treatment. 4. Active anti-tumor treatment: patients with advanced gastric cancer liver metastasis are difficult to be completely resected by surgery, so the treatment is mainly based on systemic chemotherapy, which includes fluorouracil, oxaliplatin, epirubicin, etc. Patients need to go to regular hospitals for consultation. It is necessary to go to regular hospitals for consultation and choose appropriate drugs and methods for treatment under the guidance of physicians, and not to use drugs indiscriminately.