Red spots appearing on the body in advanced stage of liver cancer may be caused by spider nevus, complications of hypersplenism and insufficient formation of coagulation factors. 1. Spider nevus: patients with advanced liver cancer have higher estrogen level in blood than normal people. Spider nevus is a kind of red blood vessel lesion caused by increased estrogen level, which looks like red spots on the body. 2. Complications of hypersplenism: patients with advanced liver cancer will have hypersplenism, which leads to the decrease of platelets and may cause red spots on the body. 3. Insufficiency of coagulation factor formation: when the liver of patients with advanced liver cancer is damaged more seriously, it will lead to insufficiency of coagulation factor formation, resulting in symptoms of extensive bleeding and leading to erythema on the body. Erythema in advanced stage of liver cancer may also be caused by eczema, etc. If the symptom of erythema in advanced stage of liver cancer persists and is not relieved, it is necessary to consult doctor in time.