Gallbladder polyps can cause painful symptoms. In clinical practice gallbladder polyps are a common disease and are classified as true polyps and pseudopolyps according to the polyp composition. Proliferative polyps are neoplastic or non-neoplastic diseases that occur as a proliferation of epithelial cells in the mucosa of the gallbladder. Pseudopolyps usually refer to monophasic water crystals of cholesterol, which further develop to form gallbladder stones. The main causes of pain caused by gallbladder polyps are the gradual enlargement of gallbladder polyps, mechanical inflammation caused by cholesterol crystals rubbing and irritating the gallbladder wall, further development leading to bacterial infection, painful and uncomfortable symptoms in the right upper abdomen caused by bacterial inflammation, and biliary colic caused by stagnation of bile when gallbladder polyps are relatively small and become embedded in the cystic duct or drain into the common bile duct. Although gallbladder polyps cause relatively little pain, they can appear as biliary colic, so gallbladder polyps can hurt.