The skull is one of the hardest bone tissues in the human body. It is composed of 23 bones of different shapes and sizes, which are articulated and occluded very precisely to form a complete and closed cranial cavity that plays an important role in protecting and supporting the brain and craniofacial organs. However, accidents can happen at any time and there are various reasons for cranial defects. Cranial defects can be very dangerous to human health and should be repaired promptly with cranial bone repair. Many general local hospitals perform skull repair surgery, mostly using titanium mesh as the skull repair material, but in fact, this material is not yet very ideal and often may have various post-operative problems. Titanium mesh is a relatively mature cranial repair material, and has been used clinically for 20 to 30 years, and has certain advancement compared with other materials in the past, but unfortunately, it still has some defects and shortcomings. According to the investigation of skull defect titanium mesh repair cases, titanium mesh has infection and rejection problems, the main symptom is that the surrounding scalp tissues do not adapt to titanium mesh, the ablation of the skin breaks down, and even causes the titanium mesh material to be exposed. In addition, the abrasion of the titanium mesh material on the scalp can cause severe scalp breakdown and exposure of the material, much like rejection. In addition to the rejection reaction, there are also some other problems, such as unsatisfactory shaping effect, sensitivity to external hot and cold environment, discomfort, affect CT magnetic resonance examination, easy to collapse and deformation by external force, etc. Therefore, the use of titanium alloy material for skull repair is not recommended at present. In fact, there are now better materials, there is a new type of polyether ether ketone PEEK material, which is a special polymer material with excellent performance, in terms of material stiffness, rigidity, strength, elasticity, thermal insulation, stability, histocompatibility, plasticity, radiation transmission and other aspects of performance and autologous cranial bone is very close, can effectively avoid the above-mentioned problems that may arise from titanium mesh material, placed in It is highly comfortable and protective after being placed in human body. PEEK cranial bone repair can achieve anatomical integrity, functional perfection and aesthetic appearance, and the results are ideal and well received.