Sacubitril valsartan is used for the treatment of hypertension and chronic heart failure, the effect is better, but the drug needs to meet the indications, follow the doctor’s instructions, and pay attention to the possible adverse reactions caused by the drug. Sacubitril valsartan is composed of two drugs, sacubitril and valsartan, which are more widely used in recent years, and the clinical effect has been effectively verified. This drug has the effect of diuretic and sodium, inhibiting sympathetic nerves and inhibiting the Rass system. Clinically, it is used with other drugs for the treatment of hypertension and chronic heart failure, and the effect is better. For patients with severe renal insufficiency should be used with caution Sacubitril valsartan, if angioedema, hypotension, hyperkalemia, pregnancy is prohibited with this type of drug. Before and during the use of the drug, it is necessary to monitor liver function, renal function, blood potassium and blood pressure levels. This drug is a prescription drug and is recommended to be applied under the supervision of a cardiovascular specialist.