Uniformly distributed parenchymal echogenic thickening of the liver is an ultrasound term. The coarsening of liver distribution may be related to viral hepatitis, alcoholic hepatitis, cirrhosis and so on. 1. Viral hepatitis: It is an infectious disease caused by different types of hepatitis viruses, with degeneration and necrosis of hepatocytes as the main lesion. With different degrees of liver inflammation and fibrosis, ultrasonography can have different manifestations. When liver inflammation and fibrosis are more obvious, liver parenchyma echogenicity is thickened and enhanced, showing short strips or small nodules, distribution is still uniform, and liver surface is not smooth. 2. Alcoholic hepatitis: toxic liver damage caused by long-term heavy drinking. Ultrasonography shows that the liver is enlarged, the echo of liver parenchyma is thickened and enhanced, the distribution is even or uneven, the echo attenuation is not obvious, the duct structure and diaphragm in the liver are clearly shown. 3. Cirrhosis: it is a common chronic progressive diffuse liver disease caused by different etiologic factors. Ultrasonography of cirrhosis shows that the liver is enlarged in the early stage and shrinks in the late stage, the surface of the liver is not smooth or slightly uneven, and the parenchymal echoes of the liver are thickened and enhanced. Liver distribution uniform parenchymal echogenic thickening can not accurately determine the disease, but also need to be combined with the characteristics of the medical history, other test results to make an accurate judgment, it is recommended to clarify the disease under the guidance of a doctor.