Low-grade squamous intraepithelial lesions LSIL are low-grade lesions that occur within the cervical epithelium.
LSIL is usually associated with HPV infection, mainly CIN I, mild atypical hyperplasia of the cervix, and flat warts, etc. HPV infection is the main causative agent of cervical intraepithelial lesions, and chronic infections, smoking, and sexually transmitted infections synergistically increase the risk of the disease.
About 60% of LSIL will resolve naturally as the squamous epithelium matures and differentiates; therefore, treatment of LSIL is usually conservative, with observation as the mainstay. Repeat HPV testing every 12 months or cervical cytology every 6 to 12 months is recommended.
If low-grade intraepithelial lesions persist for ≥2 years, treatment may be indicated. Local excision or ablative therapy can be performed if colposcopy is satisfactory, if not then cervical conization can be considered.
Prompt medical consultation and standardized treatment are recommended.