Small hepatic vein occlusion currently no special treatment, to support symptomatic treatment. Due to the critical condition of acute severe VOD, often complicated by multi-organ failure, high mortality rate, specific methods are as follows: 1, supportive therapy, including intravenous infusion of albumin or plasma, vitamin supplementation, correction of water-electrolyte and acid-base balance disorders, maintaining effective circulating blood volume, renal blood flow perfusion, perfusion volume and internal environment stability; 2, anticoagulation, dispel aggregation therapy, small dose of heparin subcutaneous injection, while applying Dextran-40; 3, water and sodium retention caused by peripheral edema and ascites, restrict sodium intake, and give diuretic, if necessary, put ascites or even dialysis; 4, to prevent infection; 5, intermittent oxygenation, conditionally give hyperbaric oxygen therapy, reduce liver edema, improve the process of systemic energy metabolism, especially the process of hepatocyte mitochondrial regeneration; 6, to promote hepatocyte regeneration drugs have a variety of, such as hepatocyte growth factor, The former two have the effect of promoting hepatocyte regeneration, while the latter promotes vasodilation around the liver sinusoids; 7, immunomodulatory therapy, the application of glucocorticoids for immunomodulation, the efficacy is better; 8, liver transplantation, for patients with severe VOD, in situ liver transplantation can be implemented.