Postoperative pathology of colon cancer is inconsistent with clinical, clinical treatment is based on pathologic diagnosis, but re-biopsy is generally recommended. Generally speaking, clinical treatment is based on pathological diagnosis, and other examination and diagnostic results are for reference. Clinical diagnosis is the probable diagnosis made by clinicians on the basis of their working experience on the comprehensive analysis of patients’ medical history, symptoms, signs and lesions. If the postoperative pathology of colon cancer is inconsistent with the clinical diagnosis, and the pathological diagnosis is different from the clinical diagnosis in terms of goodness and badness, generally the pathologist will communicate with the clinician, and biopsy again if necessary, to provide enough representative tissues for the pathological examination, in order to further clarify the diagnosis and confirm or falsify the diagnosis. If there is any doubt about the pathologic diagnosis, it is recommended to actively communicate with the attending physician to discuss the solution in order to avoid delaying the condition.