Diseases that can cause scrotal discomfort include varicocele and epididymitis, and treatments include medications such as antibiotics and surgery. 1. Varicocele: Varicocele is an abnormal tortuous expansion of the venous plexus, which often leads to vascular lesions. When the venous valves are underdeveloped or the venous reflux is impaired, it can lead to venous hypertension and cause some symptoms such as scrotal enlargement, accompanied by a feeling of swelling, and so on. Treatment includes medication such as sodium hepcidin, indomethacin, etc. If the condition is serious, it can be treated by surgery, such as vein ligation. 2. Epididymitis: When microorganisms or other factors cause epididymitis, patients often show symptoms such as painful enlargement of the scrotum, hardening, accompanied by a feeling of swelling, urinary frequency, urgency, urinary pain, etc. The treatment includes medication such as levofloxacin sodium and indomethacin. Treatment includes medication such as levofloxacin, amoxicillin, roxithromycin, etc. If the condition is serious, it can be treated by surgical excision. Drugs need to be selected under the guidance of the doctor. To summarize, when patients experience discomfort, they should go to the hospital immediately.