Cold thighs are commonly caused by low peripheral environmental temperature, peripheral neuropathy, diabetes and other chronic lesions, lower limb arterial blood supply disorders and other factors, as follows: First, the peripheral environmental temperature is too low: if you wear too little clothing, it will lead to cold thighs and manifest as thigh pain symptoms. Second, peripheral neuropathy, diabetes and other chronic lesions: will lead to abnormal sensitivity of the nerves in the lower extremities, and the patient will show clinical symptoms of cold thighs. Third, lower limb artery blood supply disorders: such as plaque formation, resulting in narrowing of blood vessels, can cause the reduction of blood supply to the thighs, and will eventually manifest as symptoms of cold thighs. Through ultrasound and electromyography, most of the causes of cold thighs can be detected, and early diagnosis and early treatment can completely reverse the symptoms. Delaying the disease will make the symptoms continue to worsen and eventually cause serious adverse consequences, affecting the patient’s normal life and work.