IgA nephropathy puncture glomerulosclerosis generally needs to be judged according to the accompanying symptoms, such as accompanied by hematuria, proteinuria, hypertension, renal failure, etc. The treatment needs to be based on different clinical manifestations, pathological types, etc. to comprehensively formulate a treatment plan.
1. With simple microscopic hematuria: generally no special treatment, but need to regularly monitor urine protein, renal function, pay attention to the prevention of infection, avoid overwork and use of nephrotoxic drugs.
2. With recurrent microscopic hematuria: for patients with recurrent microscopic hematuria after infection or worsening of urinalysis abnormality, actively control the infection and use non-nephrotoxic antibiotics, such as penicillin; for patients with recurrent episodes of chronic tonsillitis, tonsillectomy is feasible.
3. With proteinuria: It is recommended to use ACEI or ARB treatment and gradually increase the dose to be tolerated, such as captopril, valsartan and so on. For large amount of proteinuria, glucocorticoid therapy can be given, such as methylprednisolone.
4. Accompanied by hypertension: controlling blood pressure can protect renal function and delay the progression of chronic kidney disease. Clinical studies show that ACEI or ARB can control the blood pressure of IgA nephropathy patients well and reduce proteinuria.
5. With renal failure: use peritoneal dialysis or hemodialysis treatment, and renal transplantation is feasible if it meets the surgical indications.
IgA nephropathy pathological type manifested as glomerulosclerosis suggests a poor prognosis, should actively consult the doctor and standardize the treatment under the doctor’s guidance. The use of medication should be in accordance with the doctor’s prescription, do not self-medication.