B-cell lymphocytes, usually diffuse large B-cell lymphoma, are usually not related to vaccination, but may be related to infectious diseases, hematologic diseases, and immune system diseases. 1. Infectious diseases: for example, viral infections or other pathogen infections may be the triggering cause. 2. Hematologic disorders: For example, it may be related to lymphoma and lymphoblastic leukemia. 3. Immune diseases: such as rheumatoid lupus erythematosus. It is recommended that patients should go to the relevant departments of regular hospitals for a complete examination, and need to receive antinuclear antibody and autoantibody series of tests, and if necessary, need to receive bone marrow aspiration biopsy. In addition, b-cell lymphocyte triggers may have a greater harm, if necessary, need to actively accept the treatment.