Mixed ground-glass nodules may be malignant or benign, and the specific situation requires a comprehensive assessment of malignant risk in conjunction with nodule size, morphology, and calcification. Lung nodules are round-like lesions of ≤3 cm detected by chest radiographs, CT, and other imaging tests. Lung nodules can be categorized into solid nodules, pure ground-glass nodules and mixed ground-glass nodules according to their composition. Milled glass is characterized by cloudy slightly dense shadows, and mixed milled glass nodules refer to nodules with both solid and milled glass components. Mixed ground-glass nodules have a higher risk of malignancy, with about 63% being the result of malignant lesions, i.e., half of mixed ground-glass nodules are the result of malignant tumors such as bronchopulmonary carcinoma and metastatic lung cancer, and some of them are due to benign diseases such as inflammation of the lungs and misshapen tumors. Mixed ground-glass nodules are an imaging manifestation of benign and malignant lung disease and are not necessarily malignant, and the risk of malignancy needs to be further assessed based on the amount of solid component, nodule size, morphology, calcification, and margins. When mixed ground-glass nodules are detected, it is recommended that the patient go to the hospital and follow the doctor’s instructions for examination, follow-up or treatment.