Avanafil can be used by 65 year olds under doctor’s supervision in the absence of underlying medical conditions or contraindications to the drug. Avanafil is a medication used to treat erectile dysfunction in 65 year olds who are relatively frail and may contain underlying medical conditions. Some medical conditions such as patients with cardiovascular disease or at risk of cardiovascular disease and patients who are using various medications such as cyp3a4 inhibitors and other conditions may be at risk with the use of this drug. Adverse reactions may occur with the use of Avanafil in the elderly and with a lower immune system, use may result in adverse reactions such as headache, flushing, nasal congestion, nasopharyngitis, and back pain. Elderly people with poorly controlled blood pressure may also experience hypotension, which can lead to falls and serious consequences, so it needs to be used only after proof of good health and evaluation by a doctor. It is also contraindicated in older adults who are using or have previously used nitrates or guanylate cyclase stimulators or who are allergic to avanafil.