Liver spots, also known as chloasma, lacks particularly effective treatment methods at present, mainly focusing on general treatment, medication and physical therapy, and suitable treatment methods should be chosen according to the specific conditions of the patients, and there is no such thing as the best. 1. General treatment: first of all, it is necessary to pay attention to sun protection to avoid sunlight exposure, and if necessary, sunscreen can be used to reduce the skin barrier damage caused by sunlight irradiation and the increase of melanocyte activity; secondly, it can be used under the guidance of doctors to adopt anti-allergic and moisturizing medical skincare products to enhance the skin’s tolerance and to promote the repair of the skin barrier. 2. Drug therapy: including topical drugs and systemic drugs. (1) Topical medication: Hydroquinone and glycoside derivatives are commonly used as the first line of therapeutic medication for chloasma treatment, such as 2%~5% hydroquinone cream. Generally, the higher the concentration, the stronger the effect of depigmentation, but the greater the stimulation to the skin, which is prone to lead to adverse reactions such as contact dermatitis and permanent white spots on the skin; Secondly, retinoic acid can also be used, which can affect melanin metabolism and has certain therapeutic effect; in addition, fruit acid is also an effective auxiliary method for treating chloasma, but the chemical peeling of fruit acid has a certain degree of irritation to the skin, which can lead to post-inflammatory hyperpigmentation, especially the patients with dark skin color need to be cautious. (2) Systemic drugs: such as vitamin C and vitamin E, which can be taken orally or injected intravenously, effectively preventing the oxidation of dopa and inhibiting melanin synthesis; tranexamic acid, which can not only inhibit melanin synthesis, but also inhibit blood vessel formation and reduce erythema. 3. Physical therapy: such as laser, intense pulsed light, etc., but pay attention to scar formation and other adverse reactions. Specific treatment methods, need to be carried out under the guidance of a professional doctor, not blindly self-medication.