Pregnant women with total bile acids above 40.0 μmol/L or more are at risk, increasing the risk of intrauterine distress and fetal abruption. The normal value of total bile acid in pregnant women should be less than 10umol/l. Elevated total bile acid may be due to physiological reasons, such as eating too much high-fat and high-protein food before the examination. Total bile acid above 10umol/l is intrahepatic cholestasis in pregnancy, and bile acid values above 40umol/l are in severe bile acid elevation, which can be dangerous. Serum total bile acid reflects the synthesis and excretion capacity of the liver. Elevated total bile acid suggests that there is liver damage. Intrahepatic cholestasis in pregnancy may have symptoms such as itching of the skin and jaundice, and it may also have a certain effect on the fetus, increasing perinatal morbidity and mortality, and may cause fetal distress, preterm labor, amniotic fluid-fetal fecal infections, and fetal abruption. Pregnant women with increased total bile acids should seek timely medical treatment to reduce the impact on the fetus.