The insulin pump is the ultimate weapon for patients who need insulin therapy. It is especially suitable for current type 1 diabetic patients and type 2 diabetic patients with pancreatic islet failure. However, it is not an easy task to apply this “big killer” to achieve smooth blood glucose control and reach the target, but it requires some skills and tools, moreover, it needs continuous learning and practice to figure out each patient’s individual characteristics and program. In general, the regulation of pump use needs to go through the following process: First, the initial insulin dose setting, according to blood glucose levels and weight estimation, and then assigned to the basal amount and mealtime high dose. Second, monitoring blood glucose, assessing the efficacy, and adjusting the basal and mealtime high dose regimen. Third, the monitoring methods of blood glucose include multiple fingertip blood tests and continuous ambulatory blood glucose monitoring. The fine adjustment of specific basal volume can be carried out by meal skipping test or meal shifting test. Fifth, the fine regulation of the amount of mealtime high dose can be calculated by carbohydrate coefficient, insulin sensitivity index and other indexes; it can also be further improved by setting regular injection, square wave injection or double wave injection, etc. The effect of blood glucose control can be further improved by setting regular injection, square wave injection or double wave injection. Various details will also be encountered in the process of regulation above, which requires close cooperation of patients, medical care.