Mycoplasma pneumoniae positivity of 1:80 suggests a recent or previous infection with Mycoplasma pneumoniae, and the severity of the infection is based on the type of antibody positivity and the combination of clinical symptoms. Mycoplasma pneumoniae antibodies can be categorized into Mycoplasma pneumoniae IgM antibodies and IgG antibodies. 1. IgM positive: If the titer is 1:80, it suggests that the infection may be in the infected stage or recently infected with Mycoplasma pneumoniae, and if there are obvious clinical symptoms, it is necessary to combine with other laboratory results for further treatment. The commonly used antibiotics are macrolides, such as clarithromycin, azithromycin, erythromycin, etc. Quinolone antibiotics, such as levofloxacin, moxifloxacin, etc., can also be used. 2. IgG positive: usually suggests previous infection with mycoplasma, but at this time may not be in the infectious stage, general dynamic observation can be. In some patients, if IgG is positive, its titer is high or 4-fold increase in the short term, it suggests that the infection is in the recent period, if there are obvious clinical symptoms and CT manifestations, further treatment is also needed, and the choice of antibiotics is the same as the above. Therefore, when the antibody titer of Mycoplasma pneumoniae is 1:80, it suggests that there is Mycoplasma pneumoniae infection, which requires timely consultation and further analysis and treatment decision according to the specific situation.